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Diquat vs. Paraquat: Similarities, Differences, and Health Effects

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You have a clear choice when considering Diquat vs Paraquat. Both chemicals share similarities but also have significant differences that can impact your safety. It's essential to understand how each chemical affects your body. While both Diquat and Paraquat can be harmful, Paraquat is generally regarded as more dangerous. The dangers associated with these chemicals can be observed in the following ways:

  • Diquat has a higher oral LD50 in rats, indicating it is less toxic than Paraquat.

  • Diquat can damage the skin and gut, whereas Paraquat primarily harms the lungs and can lead to lung scarring.

  • Both chemicals can cause issues with the mouth and other organs, but Diquat is more likely to result in kidney and brain problems.

Being aware of these facts regarding Diquat vs Paraquat helps you stay safe and make informed choices.

Key Takeaways

  • Diquat is not as toxic as Paraquat. This makes Diquat safer for weed control. Paraquat mostly hurts the lungs. Diquat can hurt the kidneys and brain. Both chemicals can cause bad health problems. But Paraquat leads to more deaths. Always wear safety gear when using these chemicals. This helps stop you from getting exposed. Follow your local rules for using Diquat and Paraquat. This keeps everyone safe. Diquat breaks down faster in nature. This means it does not last as long as Paraquat. Get medical help right away if you think you are poisoned. You can also use organic options. This lowers your risk of being harmed by these chemicals.

Diquat vs Paraquat Overview

Diquat Basics

It is important to know about diquat before using herbicides. Diquat works fast and kills broadleaf weeds. You can find diquat in products like Diquat Dibromide 40% TK, Diquat Dibromide 20% SL, Diquat 37.4% SL, Diquat Dibromide 150 g/L SL, Diquat Dichloride 42% TK, and Diquat Dichloride 20% SL. The main part in diquat is either diquat dibromide or diquat dichloride. Diquat looks like a yellowish powder with no smell. It kills plants by breaking their cell walls, so they wilt quickly. People use diquat to control suckers in orchards, hops, and grapes. Diquat also dries out crops like potatoes and cotton before harvest. Diquat is not as toxic as paraquat, but it can still be dangerous if you do not use it right.

Paraquat Basics

Paraquat is one of the most toxic herbicides you can buy. You have to be very careful when using paraquat. Paraquat comes in different types, like Paraquat 200 g/L SL, Paraquat 276 g/L SL, Paraquat 250 g/L SL, Paraquat 42% TK, and Paraquat 45% TK. The main part in paraquat is paraquat dichloride. Paraquat is a quaternary ammonium compound and looks like a yellowish powder with no smell. It works well on grasses and some broadleaf weeds. Paraquat is sold as a liquid in many strengths. It can hurt your mouth and spread through your body. Paraquat mostly harms your lungs, liver, and kidneys. In the USA, you need a license to use paraquat because it is 'restricted use.'

Common Uses

Agricultural Use

Farmers use diquat and paraquat a lot. Diquat helps control broadleaf weeds and can slow plant growth. Paraquat works best on grasses and is used more often than diquat. Both are sprayed on grains, vegetables, peanuts, and animal feed crops. Diquat and paraquat dry out potatoes and cotton before harvest. They are also used for sucker control in orchards, hops, and grapes. In Latin America and Africa, people use more diquat and paraquat because they help crops grow better and save work.

Household Use

You might see diquat and paraquat outside of farms too. People use them in pastures and places without crops, like fencerows, airports, and electric substations. You should not use paraquat at home because it is very toxic. Sometimes, diquat is used to kill weeds in lawns and gardens, but you must be careful and follow safety rules.

Rules about these herbicides are different in each place. Paraquat is banned in Europe, except for some use in Eastern Europe. In the USA, you need a license and special training to use paraquat. Asia still uses paraquat but with more safety steps. Diquat is being used less in many places, but both are still common in Latin America and Africa.

Region

Paraquat Regulation

Diquat Regulation

Europe

Banned since late 2000s; used under controlled conditions in Eastern Europe.

Phased out in many markets.

USA

Available for licensed applicators with strict training and reporting requirements.

Not specified in the provided evidence.

Asia

Continued use with enhanced stewardship and training.

Not specified in the provided evidence.

Latin America

High-growth region for paraquat and diquat due to yield and labor efficiency.

High-growth region for paraquat and diquat.

Africa

High-growth region for paraquat and diquat due to yield and labor efficiency.

High-growth region for paraquat and diquat.

You should think about the risks and good points before picking diquat or paraquat. If you want weed control that is safer, diquat is less toxic but still needs care. Paraquat works very well but you must follow strict rules and get training. Always follow the law and safety rules to keep yourself and nature safe.

Chemical Properties

Structure Comparison

It is important to know the chemical shapes of diquat and paraquat. Their shapes change how they work and how risky they are. Look at this table to see the differences:

Aspect

Paraquat

Diquat

Molecular Structure

Two aromatic rings with steric hindrance

Similar structure but less steric hindrance

Biological Activity

Causes oxidative stress and genotoxicity

Triggers ROS formation leading to cell death

Long-term Health Effects

Linked to neurodegenerative diseases

Potential teratogenic effects

  • Paraquat is very toxic. It can build up in your kidneys and lungs.

  • Diquat causes cell death by making ROS. Its long-term effects are not as bad as paraquat.

Mode of Action

Diquat Mechanism

Diquat makes oxidative stress by creating ROS faster than paraquat. It hurts your liver and kidneys. Diquat kills cells without needing mitochondria. When diquat meets NADPH and cytochrome P450 reductase, it forms a radical. This radical gives electrons to oxygen and makes superoxide anion radicals. These radicals damage cells and cause many cells to die.

Paraquat Mechanism

Paraquat works in another way. It does not stop mitochondria as much as diquat. Paraquat is dangerous because it goes into lung tissues. It causes lung injury and scarring. Paraquat’s effects come from oxidative stress, but it is not as good at making ROS as diquat. This is why paraquat mostly hurts your lungs, while diquat affects your liver and kidneys.

Environmental Impact

You should think about the risks to nature before using diquat or paraquat. Paraquat stays in soil and water for a long time. It can build up and leave harmful leftovers. Paraquat sticks to soil and does not break down easily. Microorganisms cannot break it down well. Paraquat’s half-life in soil is between 3 and 6.6 years. Less than 1% gets broken down by microbes. This means paraquat can harm nature for many years.

Diquat acts in a different way. It breaks down faster in water. About 32% of diquat turns into water-soluble products in 22 days. But diquat can last up to 180 days in sediment-water systems. Diquat’s impact on nature is not as bad as paraquat, but you still need to be careful.

If you want to keep yourself and nature safe, pick diquat instead of paraquat. Diquat does not last as long and is less toxic, but you must follow safety rules. Always check local laws and wear protective gear. Your choices help keep you and the planet safe.

Toxicity: Diquat vs. Paraquat

Knowing how toxic diquat and paraquat are can help you stay safe. Both are very poisonous, but paraquat is even more dangerous. You should learn about the signs, how you can be exposed, and the risk of dying before using them.

Acute Poisoning

Diquat Poisoning

Diquat is not safe, even if it seems less harmful. Swallowing diquat can hurt your mouth and throat. You might throw up or have diarrhea. Early signs include burning pain in your mouth and stomach. Diquat can wear away the lining inside your body and hurt your kidneys fast. You could feel confused, weak, or have seizures. Diquat poisoning can cause kidney problems, heart issues, or even many organs to stop working. There is no cure for diquat poisoning, so you need a doctor right away. Getting help quickly can lower your chance of dying, but it depends on how much you took and how fast you get care.

Paraquat Poisoning

Paraquat is very poisonous and can kill with a small amount. If you swallow paraquat, you may get mouth sores, swelling, and strong pain. The signs get worse fast and can hurt your lungs. Paraquat attacks your lungs and causes scars, making it hard to breathe. You might stop breathing in just a few days. Your kidneys and liver can also stop working. Paraquat poisoning often ends badly, especially if you do not get help right away. Doctors can only give strong support, but many people still die.

These numbers show how risky these chemicals are:

  • Paraquat caused 300 sudden illnesses

  • Diquat caused 144 sudden illnesses

  • Paraquat led to 24 deaths

  • Diquat led to 5 deaths

  • 68% of paraquat illnesses happened at work (203 cases)

  • 29% of diquat illnesses happened at work (42 cases)

Paraquat causes more deaths and work-related sickness than diquat. Diquat is still risky, but paraquat is much more deadly.

Symptom/Outcome

Diquat Poisoning

Paraquat Poisoning

Toxicity Level

Moderate toxicity, lower than paraquat

Highly toxic

Main Clinical Manifestations

Erosion of mucous membranes, acute renal failure, cardiovascular and cerebral vascular complications, multiple organ failure

Primarily pulmonary toxicity, leading to respiratory failure

Treatment Approaches

No specific antidote; early intervention can prevent MOF

Limited treatment options; often requires aggressive supportive care

Prognosis

Varies; no biomarkers for severity or prognosis

Poor prognosis, especially with delayed treatment

Chronic Effects

Long-term exposure to diquat and paraquat can hurt your body. These chemicals can damage your organs and shorten your life. Paraquat can scar your lungs, cause kidney failure, and hurt your heart and throat. Diquat can cause kidney injury, harm cell walls, and start inflammation. It can make scarring worse and damage your kidneys more. Diquat can also mess up mitochondria, kill cells, and cause liver swelling. It may make your immune system attack your tissues. Both chemicals mess up autophagy, which can damage more organs over time.

Exposure Routes

You can come into contact with diquat and paraquat in different ways. Knowing how this happens helps you avoid getting poisoned.

Route of Exposure

Description

Inhalation

Breathing in airborne aerosols of pesticides.

Ingestion

Consuming residues in food and water.

Dermal Contact

Skin contact with contaminated surfaces or direct application.

Most poisonings happen when you breathe in or swallow these chemicals by accident. Touching them can also hurt you, especially if your skin is broken. Always wear safety gear and follow the rules to protect yourself.

Clinical Patterns, Organ Damage, and Mortality

It is important to know how diquat and paraquat affect your body. Paraquat is very toxic and kills more people. It mainly hurts your lungs and can make you stop breathing. Diquat is also toxic but less likely to kill you. It targets your kidneys and brain and can cause organ failure if you do not get help. Both can cause many organs to fail, but paraquat kills more often.

To stay safe, try to use other options if you can. Always wear protective gear and follow all safety steps. Learn the signs of poisoning early. Acting fast can save your life. Never ignore how dangerous these chemicals are.

Diquat Health Effects

Symptoms

Skin & Eye Irritation

You need to protect your skin and eyes when you handle diquat. This chemical can cause strong irritation. If you touch diquat, your skin may turn red, itch, or even blister. You can also feel burning or stinging. Diquat can damage your eyes if it gets in them. You might suffer from severe eye injury or corneal burns. You could lose vision if you do not wash your eyes right away. Diquat is toxic, so you must wear gloves and goggles every time you use it.

Organ Damage

Diquat does not just hurt your skin and eyes. It can cause serious organ damage. If you swallow diquat, you may feel pain in your mouth and throat. You could get nosebleeds, headaches, or a sore throat. Diquat can make you cough and feel weak. You might have convulsions or tremors. Over time, diquat can soften your fingernails and change their color. You may feel lethargic or lose weight. Diquat can cause your pupils to dilate and make it hard to breathe. If you take too much, diquat can lead to death.

Here is a table showing the most common symptoms you may experience from diquat exposure:

Symptom Type

Specific Symptoms

Acute Effects

Convulsions, tremors, oral or nasal irritation, nosebleeds, headache, sore throat, coughing

Chronic Effects

Softening and color changes in fingernails, severe eye injury, corneal burns

Delayed Symptoms

Lethargy, pupil dilation, respiratory distress, weight loss, weakness, death

You must act fast if you notice any of these effects. Diquat toxicity can get worse quickly. Always seek medical help if you feel sick after exposure.

Severity & Outcomes

Diquat is toxic and can cause severe health effects. The case fatality rate for diquat poisoning is high, at 36.8%. You face greater risk if you are older or if you take a larger amount. Survivors usually get help later and take less diquat. The median age for survivors is 26 years, while fatalities average 33 years. If you take more diquat, your plasma concentration rises and your risk increases. Survivors had lower plasma diquat levels (97.8 ng/mL) compared to fatalities (1,531 ng/mL).

  • You can survive diquat poisoning if you act quickly and take a small amount.

  • You face higher risk if you delay treatment or take more diquat.

  • You must watch for symptoms and get help right away.

  • Diquat toxicity can cause lasting effects, so you need follow-up care.

Diquat is toxic and can harm your body in many ways. You must respect its power and protect yourself. Always use safety gear and follow instructions. If you notice symptoms, seek help fast. You can reduce your risk and protect your health.

Paraquat Health Effects

Symptoms

Pulmonary Injury

Handling paraquat is very risky. This chemical can badly hurt your lungs. You might have trouble breathing soon after touching it. Paraquat attacks your lungs and causes damage. You could feel pain in your chest and a burning throat. Your lungs might fill with fluid, making it hard to breathe. Pulmonary injury from paraquat can cause high blood pressure in your lungs. Breathing may become painful and very hard. Paraquat can quickly make lung problems worse. You need to get help fast if you have trouble breathing.

The worst thing paraquat does is hurt your lungs. You can get sudden lung injury and swelling. Paraquat targets your lungs and causes scarring. You might not be able to breathe well anymore. Lung injury can lead to breathing failure and even death.

Other Organ Effects

Paraquat does not just hurt your lungs. It can also damage other parts of your body. You might feel sick to your stomach and throw up. You could feel weak and have pain all over. Paraquat can hurt your kidneys very fast. Your skin might swell up. If your liver is hurt, you could turn yellow. Paraquat can burn your mouth and throat. You might have trouble breathing, called dyspnea. Paraquat can hurt many organs and cause them to stop working.

  • Some common symptoms are:

    • Nausea

    • Vomiting

    • Weakness

    • Trouble breathing

    • Yellow skin

    • Body pain

You need to notice these signs early. Paraquat is very poisonous and acts fast. Get medical help right away if you see any of these signs.

Severity & Outcomes

Paraquat poisoning is very serious. You have a high chance of dying if you get poisoned. The death rate for paraquat is much higher than for diquat. Look at this table to see the difference:

Substance

Mortality Rate

Significance

Paraquat

55.6%

P = 0.000

Diquat

25.2%

P = 0.000

Paraquat kills more people because it causes bad lung injury and organ failure. You need to know that paraquat is very dangerous. It can hurt your lungs, kidneys, and liver. Paraquat poisoning gets worse fast, so there is not much time to get help. Always wear safety gear and follow the rules. Try not to use paraquat if you can pick something safer.

Paraquat can cause very bad and deadly health problems. Take the danger seriously and act fast if you are exposed. Watch for lung and organ problems. Get medical help right away. Protect yourself and do not take risks.

Diagnosis & Treatment

Recognizing Poisoning

You need to spot poisoning fast to help people. Look for mouth pain, trouble breathing, skin problems, and confusion. If someone throws up, has diarrhea, or feels weak, act quickly. Watch for changes in how they act or sudden sickness after touching herbicides. Finding poisoning early lets you start care sooner and helps people get better.

Tip: Always ask if someone was near weed killers. This helps you find poisoning and start care right away.

Medical Diagnosis

Doctors use tests to check for poisoning. First, they use a GICA strip. This test finds diquat or paraquat in blood or urine. The GICA strip works fast and finds tiny amounts, as low as 20 ng/mL. It does not react with other things, so results are correct. Next, doctors use HILIC-UV. This test measures the exact amount of poison in the sample. HILIC-UV can find as little as 0.2 μg/mL and gives clear numbers. Using both tests helps doctors know if someone is poisoned and pick the best care.

Treatment Options

You must help people fast if they show signs of poisoning. Start treatment right away to help them survive. Focus on emergency care and long-term support.

Emergency Response

Start care as soon as possible. Take off dirty clothes and wash skin with water. Give activated charcoal if poison was swallowed. This stops the body from taking in more poison. Help with breathing and heart rate. Doctors may use charcoal hemoperfusion for paraquat poisoning. This works best when plasma levels are under 3 mg/L. It helps remove poison from the blood. Immunosuppressive drugs like cyclophosphamide, methylprednisolone, and dexamethasone can lower swelling. N-acetyl cysteine may help some people by fighting free radicals. Watch patients closely and change care as needed.

Treatment Modality

Effectiveness

Notes

Superoxide dismutase

Not effective in humans

Reduced mortality in animal models

Vitamin C, Vitamin E, Desferoxime

Not helpful

No prevention of lung damage

N-Acetyl cysteine

Some success in few cases

Acts as a free radical scavenger

Immunosuppression (Cyclophosphamide, Methylprednisolone, Dexamethasone)

Widely used

Aims to inhibit inflammatory response

Charcoal Hemoperfusion

Beneficial for plasma levels ≤ 3 mg/L

Enhances elimination of Paraquat

Long-Term Care

Keep helping patients after the emergency is over. They need medical support to get better from poisoning. Check how their organs work and look for late effects. Give care for lungs, kidneys, and liver. Some people may need physical therapy if they feel weak or have trouble breathing. Have regular doctor visits to check progress. Teach patients to stay away from poison and follow safety steps. You help people heal and stop more poisoning by giving long-term care.

Note: Acting fast and giving good care can save lives. Always use the best tests and treatments for people exposed to diquat or paraquat.

Safety & Regulation

Handling Precautions

You need to be careful with herbicides every time you use them. Diquat and paraquat can hurt you if you do not follow safety steps. Always wear gloves, goggles, and long sleeves. Wash your hands after you touch any herbicide. Never eat, drink, or smoke while using herbicides. Keep these chemicals away from kids and pets. Store herbicides in a locked cabinet. Read the label before you use diquat or paraquat. Labels tell you about dangers and risks. Follow the instructions exactly.

Tip: Use herbicides only in places with good airflow. Clean up spills of diquat or paraquat right away. Do not let these chemicals touch your skin or eyes. If you feel sick after using herbicides, get help fast.

Here are some safety steps you should follow:

Safety Measure

Description

New packaging

Stops moving paraquat except into proper equipment

Training

Certified users must learn how to store and handle herbicides

Labeling

Labels show dangers and risks

Application method

No spraying from handheld or backpack equipment

Applicator certification

Only certified people can use these pesticides

Regulatory Status

You need to know the rules before using diquat or paraquat. Paraquat is more restricted because it is much more toxic. Many countries banned paraquat because it is dangerous. Diquat is less toxic, so fewer places ban it. Check your local laws before buying or using any herbicide.

Region

Regulatory Status

United States

Paraquat is restricted and only licensed people can use it.

European Union

Paraquat has been banned since 2007 because it can hurt your nerves.

Asia

Banned in China (2017) and Thailand (2019); still used in India even with some rules.

Paraquat is banned in Europe and parts of Asia. You need a license to use paraquat in the United States. Diquat is not banned in most places, but you must follow strict safety rules.

Environmental Safety

You must protect nature when you use herbicides. Paraquat stays in soil for years and can harm plants and animals. Diquat breaks down faster but can still cause problems if used wrong. Always use herbicides far from water sources. Do not spray diquat or paraquat on windy days. Never use herbicides near streams, ponds, or wells. Follow all safety steps to stop pollution.

Note: You help keep nature safe when you use herbicides the right way. Pick diquat if you want a safer choice, but always follow the rules. Protect yourself, your family, and the planet.

If you want to control weeds safely, respect the power of diquat and paraquat. Follow all handling steps, check the rules, and use environmental safety measures. Make smart choices and stay safe.

Diquat vs. Paraquat Comparison

Key Differences Table

You need to see the facts clearly when you compare diquat vs paraquat. The table below shows the most important differences. This will help you make a smart and safe choice.

Feature

Diquat

Paraquat

Main Use

Broadleaf weed control, crop desiccation

Grass and weed control, crop desiccation

Toxicity to Humans

High, but lower than paraquat

Extremely high

96 h LC50 (mg/L)

Significantly lower than paraquat

1.49–1.75 (very toxic to fish)

Main Health Risks

Kidney and brain damage, skin and eye irritation

Severe lung injury, multi-organ failure

Environmental Impact

Breaks down faster in water, less persistent

Stays in soil for years, highly persistent

Regulatory Status

Fewer bans, still regulated

Banned or restricted in many countries

Worker Safety

Requires PPE, less risk than paraquat

Requires strict PPE, very high risk

Household Use

Sometimes allowed with caution

Not recommended, very dangerous

Note: Paraquat shows much higher toxicity to aquatic life. Diquat is still dangerous, but you face less risk if you use it with care.

Practical Implications

You want to protect your health and your crops. The choice between diquat vs paraquat affects both. Many people worry that banning paraquat could hurt crop yields or farmer incomes. You do not need to worry. Over 67 countries have banned paraquat without seeing drops in productivity. Most regulators agree that farmer incomes did not suffer after the ban. You can use diquat as an alternative and still get good results in your fields.

You must remember that diquat is not risk-free. You still need to wear gloves, goggles, and follow all safety steps. Diquat can cause serious health problems if you do not handle it properly. Paraquat, on the other hand, brings much higher risks. Even a small mistake can lead to deadly poisoning. You should never use paraquat at home. Only trained and certified workers should handle it, and only when absolutely necessary.

  • If you want to keep your workers safe, choose diquat over paraquat.

  • If you want to avoid legal trouble, always check the rules in your area.

  • If you want to protect the environment, pick the option that breaks down faster and leaves less residue.

Choosing Safely

You have the power to make the right choice for your safety and your land. When you look at diquat vs paraquat, you see that diquat offers a safer path. You still need to respect its dangers, but you lower your risk of severe poisoning and long-term harm. Paraquat brings a much higher chance of deadly accidents and environmental damage.

Follow these steps to choose safely:

  1. Read the label every time. You need to know the risks before you use any herbicide.

  2. Wear the right gear. Gloves, goggles, and long sleeves protect your skin and eyes.

  3. Keep chemicals locked away. You stop accidents when you store them safely.

  4. Never use paraquat at home. Only professionals with training should handle it.

  5. Choose diquat if you need a fast-acting herbicide. You get results with less risk.

  6. Stay updated on local laws. Rules change, and you must follow them to avoid fines or harm.

  7. Protect water sources. Do not spray near streams, ponds, or wells.

Tip: You can control weeds and protect your health at the same time. Make the smart choice. Use diquat with care and avoid paraquat unless you have no other option.

You do not have to risk your life or the environment to get good weed control. Diquat vs paraquat is a clear choice when you put safety first. Take action today. Choose the safer option and follow every safety rule. Your health, your family, and your land depend on it.

You can get sick from diquat or paraquat. Both chemicals are dangerous, but paraquat is worse and has more rules. Diquat can hurt your kidneys and brain. Paraquat harms your lungs and can cause serious poisoning. You need to follow safety steps and watch for symptoms. Pick organic foods, wash fruits and vegetables, peel the outside, and drink clean water. Stay away from places where these chemicals are used. Only trained people should use paraquat, and it must be kept away from kids. Wear safety gear and never put paraquat in other bottles. If you see signs of poisoning, get medical help fast. Making smart choices keeps you and your community safe.

  1. Pick organic foods and wash all fruits and vegetables.

  2. Peel and cut off the outside of produce.

  3. Drink clean, filtered water.

  4. Learn about how pesticides are used.

  5. Help farms that use safe methods.

  6. Grow your own food with organic ways.

  7. Stay away from places where chemicals are sprayed.

You lower your risk of poisoning by doing these things. Start now to protect yourself from diquat and paraquat.

FAQ

What makes paraquat more dangerous than diquat?

You face higher risks with paraquat. It causes severe lung damage and has a higher death rate. Even small amounts can poison you quickly.

Can you use diquat or paraquat at home?

You should never use paraquat at home. Diquat is sometimes allowed, but you must follow all safety steps and keep it away from children.

How can you protect yourself when handling these herbicides?

Wear gloves, goggles, and long sleeves. Always read the label. Store chemicals in a locked cabinet. Wash your hands after use.

What should you do if you suspect poisoning?

Act fast. Call for medical help right away. Remove contaminated clothing. Rinse skin or eyes with water. Do not wait for symptoms to get worse.

Are diquat and paraquat harmful to the environment?

Yes, both can harm nature. Paraquat stays in soil for years. Diquat breaks down faster but can still pollute water. Use them far from streams and ponds.

Is it possible to avoid exposure to these chemicals?

You can lower your risk. Choose organic foods. Wash produce well. Drink clean water. Support farms that use safer methods.

Why do some countries ban paraquat but not diquat?

Paraquat is extremely toxic and causes more deaths. Many countries ban it to protect people and nature. Diquat is less toxic, so it faces fewer bans.

What are the signs of diquat or paraquat poisoning?

You may notice mouth pain, trouble breathing, skin irritation, weakness, or confusion. Watch for vomiting or diarrhea. Seek medical help if you see these signs.

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